Objective: Diabetes is the major and leading cause of death, poor quality of life and organ failure which emphasizes the importance of accurate measuring of body glucose. Carbon nanotube (CNT) biosensors exhibit great sensitivity and selectivity for glucose in blood and body fluids. The most recent progresses on the development of various methods of CNT biosensors for glucose detection are summarized in this review. Methods: For this review, online search of different sources such as PubMed, ISI and Scopus resulted in finding 34 articles correlated with CNT detector and its application in diabetes sensing. Results: The results showed advanced methods of CNT sensor functionalization with various modifiers like polyaniline and techniques such as self-assembly layer-by-layer process. These point-of-care solution-phase nanotube biosensors have significant potency to monitor blood glucose non-invasively and eliminate painful finger prick procedure. Conclusion: In this study, it was concluded that appropriate surface modification of CNT biosensors could play an important role in real-time diagnosis of diabetes.